TMEM130

Across TCGA patient cohorts, TMEM130 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM130-associated genes across cancer lineages are Src, EGFR_pY1068, and A-Raf_pS299. Each is linked with TMEM130 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM130-to-partner and partner-to-TMEM130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by TMEM130-low versus TMEM130-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM130→partner) and Y-score (partner→TMEM130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src →	-0.241	-2.983	.013	.034	3	2
UCEC	EGFR_pY1068 →	-0.340	-3.459	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.164	-1.807	<.001	.027	3	1
UCEC	FoxM1 →	+0.278	+3.594	.009	.001	3	1
UCEC	Gab2 →	+0.477	+3.584	.001	.002	3	1
UCEC	Ku80 →	+0.282	+2.125	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Src by TMEM130 expression — SKCM

Explore this box plot interactively →