TMEM130

Across TCGA cell cohorts, TMEM130 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,426 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM130-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of myoblast fusion, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with TMEM130 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM130-to-partner and partner-to-TMEM130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by TMEM130-low versus TMEM130-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM130→partner) and Y-score (partner→TMEM130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of myoblast fusion →	+0.072	+1.371	<.001	<.001	3	11
CNS	Negative regulation of myoblast fusion →	+0.089	+1.440	<.001	<.001	3	11
CNS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.066	+1.005	<.001	.008	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.083	+0.480	.002	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Protein targeting to vacuole involved in autophagy →	+0.160	+0.480	<.001	.004	3	10
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.071	+0.318	.005	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,426 associations by consensus.

Regulation of myoblast fusion by TMEM130 expression — CNS

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