TMEM130

Across TCGA cell cohorts, TMEM130 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM130-associated genes across cancer lineages are ZMYND8, SH3GL2, and NDUFC1. Each is linked with TMEM130 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM130-to-partner and partner-to-TMEM130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMYND8 grouped by TMEM130-low versus TMEM130-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM130→partner) and Y-score (partner→TMEM130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZMYND8 →	-0.739	-3.278	.005	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.599	+2.667	<.001	.007	3	1
LARGE_INTESTINE	NDUFC1 →	+0.633	+3.364	.003	.002	3	1
LARGE_INTESTINE	WRAP73 →	+0.561	+3.364	.002	.002	3	1
LARGE_INTESTINE	ATP5PB →	+0.513	+3.364	.001	.002	3	1
LARGE_INTESTINE	SDHB →	+0.518	+3.451	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

ZMYND8 by TMEM130 expression — LARGE_INTESTINE

Explore this box plot interactively →