TMEM129

Across TCGA pan-cancer cohorts, TMEM129 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM129 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM129 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM129 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC and GBM are the cancer types where TMEM129 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.490	1.000	.036	2	view →
GBM	DFS	Tertile	All	0.830	0.627	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM129–HNSC (DFS)

Open the HNSC breakdown →