TMEM129

Across TCGA patient cohorts, TMEM129 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM129-associated genes across cancer lineages are ERK2, Notch1, and ATM. Each is linked with TMEM129 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM129-to-partner and partner-to-TMEM129 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TMEM129-low versus TMEM129-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM129→partner) and Y-score (partner→TMEM129) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.296	+3.000	.007	.037	3	1
UCEC	Notch1 →	+0.211	+3.000	.009	.037	3	1
UCEC	ATM →	-0.663	-3.000	.011	.037	3	1
UCEC	PCNA →	+0.402	+3.000	.001	.037	2	1
UCEC	Lck →	+0.420	+3.000	<.001	.037	1	1
UCEC	Caspase-7-cleavedD198 →	+1.511	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ERK2 by TMEM129 expression — UCEC

Explore this box plot interactively →