TMEM129

Across TCGA cell cohorts, TMEM129 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM129-associated genes across cancer lineages are TMCO5A, NKX2-6, and KRTAP21-2. Each is linked with TMEM129 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM129-to-partner and partner-to-TMEM129 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by TMEM129-low versus TMEM129-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM129→partner) and Y-score (partner→TMEM129) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.135	+5.201	<.001	.006	3	1
BLOOD_Lymphoma	OR10P1 →	+0.624	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TMCO5A by TMEM129 expression — LARGE_INTESTINE

Explore this box plot interactively →