TMEM128

Across TCGA patient cohorts, TMEM128 mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM128-associated genes across cancer lineages are SNORD116-22, PGAP2, and NOCT. Each is linked with TMEM128 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM128-to-partner and partner-to-TMEM128 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-22 grouped by TMEM128-low versus TMEM128-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM128→partner) and Y-score (partner→TMEM128) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD116-22 →	+0.243	+3.267	.007	.005	3	1
UCEC	PGAP2 →	+0.535	+3.470	.003	.003	3	1
UCEC	NOCT →	+0.778	+3.330	.001	.005	3	1
UCEC	PANK4 →	+0.567	+3.223	<.001	.009	3	1
UCEC	MED27 →	+0.540	+3.254	.001	.008	3	1
UCEC	MON1A →	+0.646	+3.378	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

SNORD116-22 by TMEM128 expression — UCEC

Explore this box plot interactively →