TMEM128

Across TCGA patient cohorts, TMEM128 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM128-associated genes across cancer lineages are p27_pT198, PCNA, and TSC1. Each is linked with TMEM128 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM128-to-partner and partner-to-TMEM128 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by TMEM128-low versus TMEM128-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM128→partner) and Y-score (partner→TMEM128) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.153	+3.169	.009	.020	3	1
UCEC	PCNA →	+0.242	+3.169	.041	.020	2	1
UCEC	TSC1 →	-0.257	-3.169	.006	.020	2	1
UCEC	ATM →	-0.807	-3.169	.001	.020	1	1
UCEC	CD20 →	+0.205	+3.169	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p27_pT198 by TMEM128 expression — UCEC

Explore this box plot interactively →