TMEM127

Across TCGA pan-cancer cohorts, TMEM127 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM127 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TMEM127 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM127 expression acts as an unfavorable survival marker.

OV, BRCA, and SKCM are the cancer types where TMEM127 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.278	0.843	<.001	36	view →
BRCA	OS	Median	All	0.514	0.963	.006	16	view →
SKCM	OS	Median	All	0.361	0.786	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM127–OV (OS)

Open the OV breakdown →