TMEM127

Across TCGA pan-cancer cohorts, TMEM127 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM127 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TMEM127 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM127 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where TMEM127 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.755	0.870	.021	11	view →
GBM	DFS	Tertile	All	0.834	0.527	.005	7	view →
CCRCC	DFS	Median	All	0.723	0.158	.026	2	view →
LSCC	DFS	Quartile	III,IV	0.475	0.979	.023	2	view →
LUAD	DFS	Quartile	III,IV	1.000	0.375	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM127–PDAC (OS)

Open the PDAC breakdown →