TMEM127

Across TCGA patient cohorts, TMEM127 protein abundance is significantly associated with the RNA expression of many other genes, with 2,914 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM127-associated genes across cancer lineages are CD40LG, PTBP1, and TMEM214. Each is linked with TMEM127 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM127-to-partner and partner-to-TMEM127 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM127 versus CD40LG in LUAD, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM127→partner) and Y-score (partner→TMEM127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD40LG →	-1.023	-0.702	<.001	<.001	3	2
LUAD	PTBP1 →	+0.402	+0.421	<.001	.001	3	2
LUAD	TMEM214 →	+0.447	+0.541	.006	.004	3	2
UCEC	ELF1 →	-0.706	-0.785	.006	.008	3	2
LUAD	PRADC1 →	+0.634	+0.620	<.001	.001	3	2
HNSC	GPR174 →	-0.792	-0.331	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,914 associations by consensus.

TMEM127 vs CD40LG — LUAD

Explore this scatter interactively →