TMEM127

Across TCGA patient cohorts, TMEM127 mutation is significantly associated with the RNA expression of many other genes, with 931 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM127-associated genes across cancer lineages are GTF2H5, LINC01145, and DOC2B. Each is linked with TMEM127 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM127-to-partner and partner-to-TMEM127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF2H5 grouped by TMEM127-low versus TMEM127-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM127→partner) and Y-score (partner→TMEM127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GTF2H5 →	+0.338	+2.609	.008	.005	3	1
UCEC	LINC01145 →	-0.438	-2.169	.001	.003	3	1
UCEC	DOC2B →	-1.266	-2.662	<.001	<.001	3	1
UCEC	NOL12 →	+0.349	+2.202	.001	.001	3	1
UCEC	C8orf89 →	-0.288	-2.727	.008	.003	3	1
UCEC	IGHV2-70 →	+1.468	+2.230	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 931 associations by consensus.

GTF2H5 by TMEM127 expression — UCEC

Explore this box plot interactively →