TMEM127

Across TCGA patient cohorts, TMEM127 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM127-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with TMEM127 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM127-to-partner and partner-to-TMEM127 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TMEM127-low versus TMEM127-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM127→partner) and Y-score (partner→TMEM127) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.503	+3.169	<.001	.018	3	1
UCEC	EGFR_pY1068 →	-0.310	-3.000	.002	.001	3	1
UCEC	ERK2 →	+0.250	+2.459	.001	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-2.690	.012	.006	3	1
UCEC	GAPDH →	+0.605	+3.321	.006	.009	3	1
UCEC	INPP4B →	-0.297	-2.115	.026	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by TMEM127 expression — UCEC

Explore this box plot interactively →