TMEM126A

Across TCGA pan-cancer cohorts, TMEM126A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM126A data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM126A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM126A expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, CCRCC, and HNSC are the cancer types where TMEM126A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.910	.011	30	view →
CCRCC	OS	Median	III,IV	0.202	0.985	.007	28	view →
HNSC	DFS	Tertile	IV	0.799	0.490	.008	14	view →
PDAC	OS	Median	III,IV	0.314	0.550	.018	9	view →
LSCC	OS	Tertile	All	1.000	0.925	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM126A–COAD (DFS)

Open the COAD breakdown →