TMEM123

Across TCGA patient cohorts, TMEM123 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM123-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD8+ Tem. Each is linked with TMEM123 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM123-to-partner and partner-to-TMEM123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by TMEM123-low versus TMEM123-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM123→partner) and Y-score (partner→TMEM123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.045	+3.108	<.001	.011	3	1
UCEC	CD8+ Tcm →	+0.058	+3.198	<.001	.009	3	1
UCEC	CD8+ Tem →	+0.005	+5.258	<.001	.029	3	1
UCEC	aDC →	+0.117	+2.818	.009	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ T-cells by TMEM123 expression — UCEC

Explore this box plot interactively →