TMEM121B

Across TCGA pan-cancer cohorts, TMEM121B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM121B data layer compared with 29 for mass-spec protein.

The strongest signal is observed in prostate adenocarcinoma (PRAD), where higher TMEM121B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM121B expression acts as an unfavorable survival marker.

PRAD, UCEC, and SKCM are the cancer types where TMEM121B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	0.100	0.340	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM121B–PRAD (DFS)

Open the PRAD breakdown →