Across TCGA patient cohorts, TMEM121 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,255 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM121-associated proteins across cancer lineages are SQOR, SEC23B, and DENND2D. Each is linked with TMEM121 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM121-to-partner and partner-to-TMEM121 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121→partner) and Y-score (partner→TMEM121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SQOR →	-0.574	-0.658	<.001	<.001	3	5
CCRCC	SEC23B →	-0.305	-0.725	<.001	<.001	3	5
GBM	DENND2D →	-0.622	-0.671	.005	.008	3	5
COAD	FSTL1 →	+0.546	+0.593	<.001	<.001	3	5
UCEC	FN1 →	+0.669	+0.521	.002	.008	3	5
COAD	RAB23 →	+0.719	+0.515	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,255 associations by consensus.

Exploration

TMEM121 survival (RNA) · tumor vs normal (RNA) · all TMEM121 data types