Across TCGA patient cohorts, TMEM121 mutation is significantly associated with the RNA expression of many other genes, with 534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM121-associated genes across cancer lineages are LYZL1, RNU1-17P, and RNU6-1066P. Each is linked with TMEM121 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM121-to-partner and partner-to-TMEM121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121→partner) and Y-score (partner→TMEM121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LYZL1 →	+0.053	+5.418	<.001	.005	3	1
CESC	RNU1-17P →	+0.378	+5.103	<.001	.008	3	1
CESC	RNU6-1066P →	+0.344	+5.418	.002	.005	3	1
CESC	SSX9P →	+0.100	+6.342	<.001	.001	3	1
CESC	RNA5SP198 →	+0.411	+6.144	<.001	.001	3	1
CESC	LINC00457 →	+0.058	+5.201	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 534 associations by consensus.

Exploration

TMEM121 survival (RNA) · tumor vs normal (RNA) · all TMEM121 data types