Across TCGA patient cohorts, TMEM121 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM121-associated genes across cancer lineages are A-Raf_pS299, MSH2, and p62 Lck ligand. Each is linked with TMEM121 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM121-to-partner and partner-to-TMEM121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121→partner) and Y-score (partner→TMEM121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.198	-3.169	<.001	.019	3	1
UCEC	MSH2 →	-0.268	-2.459	.016	.020	3	1
UCEC	p62 Lck ligand →	+0.515	+3.169	.001	.018	3	1
UCEC	p90 RSK →	+0.225	+3.331	.015	.005	3	1
UCEC	Annexin-1 →	+0.900	+3.189	<.001	.010	3	1
UCEC	TIGAR →	+0.227	+3.611	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

TMEM121 survival (RNA) · tumor vs normal (RNA) · all TMEM121 data types