Across TCGA cell cohorts, TMEM121 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM121-associated genes across cancer lineages are PRR20B, PRR20A, and LEUTX. Each is linked with TMEM121 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM121-to-partner and partner-to-TMEM121 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121→partner) and Y-score (partner→TMEM121) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRR20B →	+0.049	+5.169	<.001	.005	3	1
BREAST	PRR20A →	+0.049	+5.169	<.001	.005	3	1
BREAST	LEUTX →	+0.367	+5.169	<.001	.005	3	1
BREAST	PRR20D →	+0.049	+5.169	<.001	.005	3	1
BREAST	PRR20E →	+0.049	+5.169	<.001	.005	3	1
BREAST	GAGE12F →	+0.427	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

TMEM121 survival (RNA) · tumor vs normal (RNA) · all TMEM121 data types