Across TCGA pan-cancer cohorts, TMEM120B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM120B data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM120B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM120B expression acts as an unfavorable survival marker.

UCEC, STAD, and HNSC are the cancer types where TMEM120B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	OS	Median	III,IV	0.003	0.630	<.001	6	view →
HNSC	OS	Median	All	0.123	0.397	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM120B tumor-vs-normal RNA expression · all TMEM120B data types