Across TCGA patient cohorts, TMEM120B mutation is significantly associated with the RNA expression of many other genes, with 1,410 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM120B-associated genes across cancer lineages are ELAVL4-AS1, ANKRD9, and CHAF1B. Each is linked with TMEM120B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM120B-to-partner and partner-to-TMEM120B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM120B→partner) and Y-score (partner→TMEM120B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ELAVL4-AS1 →	+0.150	+5.602	.001	.004	3	2
UCEC	ANKRD9 →	+0.485	+3.397	.002	.004	3	2
UCEC	CHAF1B →	+0.701	+3.584	<.001	.002	3	2
UCEC	SLBP →	+0.511	+2.716	.006	.003	3	2
UCEC	TMEM161B →	+0.524	+3.502	.001	.002	3	2
UCEC	IDH3A →	+0.613	+2.815	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,410 associations by consensus.

Exploration

TMEM120B survival (RNA) · tumor vs normal (RNA) · all TMEM120B data types