Across TCGA patient cohorts, TMEM120B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM120B-associated genes across cancer lineages are ERK2, IGFBP2, and MEK1. Each is linked with TMEM120B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM120B-to-partner and partner-to-TMEM120B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM120B→partner) and Y-score (partner→TMEM120B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.186	+2.000	.032	.032	3	1
UCEC	IGFBP2 →	-1.031	-3.169	<.001	.018	3	1
UCEC	MEK1 →	+0.427	+3.321	.009	.010	3	1
UCEC	p62 Lck ligand →	+0.398	+2.999	.006	.035	3	1
UCEC	ARID1A →	-0.231	-2.577	.006	.011	3	1
UCEC	Bcl-2 →	-0.352	-2.999	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TMEM120B survival (RNA) · tumor vs normal (RNA) · all TMEM120B data types