Across TCGA cell cohorts, TMEM120B mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible TMEM120B-associated genes across cancer lineages are TGM6, MOS, and SPRR1A. Each is linked with TMEM120B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM120B-to-partner and partner-to-TMEM120B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM120B→partner) and Y-score (partner→TMEM120B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TGM6 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MOS →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Leukemia	SPRR1A →	+0.287	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

TMEM120B survival (RNA) · tumor vs normal (RNA) · all TMEM120B data types