Across TCGA patient cohorts, TMEM116 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,117 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM116-associated proteins across cancer lineages are VEZF1, ZKSCAN1, and PPP1R18_S368. Each is linked with TMEM116 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM116-to-partner and partner-to-TMEM116 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM116→partner) and Y-score (partner→TMEM116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VEZF1 →	+0.323	+0.423	.005	<.001	3	5
BRCA	ZKSCAN1 →	+0.371	+0.695	<.001	<.001	3	5
LSCC	PPP1R18_S368 →	-0.529	-0.941	<.001	<.001	3	5
LUAD	MYEF2 →	+0.589	+0.628	<.001	<.001	3	5
GBM	NRBF2 →	-0.394	-0.401	<.001	<.001	3	5
LSCC	UNC13D →	-0.447	-0.975	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,117 associations by consensus.

Exploration

TMEM116 survival (RNA) · tumor vs normal (RNA) · all TMEM116 data types