Across TCGA patient cohorts, TMEM116 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM116-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and GATA6. Each is linked with TMEM116 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM116-to-partner and partner-to-TMEM116 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM116→partner) and Y-score (partner→TMEM116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.250	+3.321	.014	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.167	-2.449	.005	.019	3	1
UCEC	GATA6 →	-0.207	-3.000	.005	.035	3	1
UCEC	ACC1 →	+0.446	+3.169	.011	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.222	-3.169	.006	.019	3	1
UCEC	Ku80 →	+0.352	+3.183	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

TMEM116 survival (RNA) · tumor vs normal (RNA) · all TMEM116 data types