Across TCGA cell cohorts, TMEM116 RNA expression is significantly associated with the RNA expression of many other genes, with 8,880 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TMEM116-associated genes across cancer lineages are CARF, TCTEX1D2, and C12orf76. Each is linked with TMEM116 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMEM116-to-partner and partner-to-TMEM116 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM116→partner) and Y-score (partner→TMEM116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CARF →	+0.922	+1.386	<.001	<.001	2	13
BONE	TCTEX1D2 →	+1.501	+0.646	.002	<.001	3	11
OVARY	C12orf76 →	+0.893	+1.112	<.001	<.001	3	11
LUNG_SCLC	C5 →	+1.324	+0.611	<.001	.007	2	12
PANCREAS	ACAD10 →	+1.066	+0.801	<.001	.003	3	11
OESOPHAGUS	KCTD18 →	+1.169	+1.510	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,880 associations by consensus.

Exploration

TMEM116 survival (RNA) · tumor vs normal (RNA) · all TMEM116 data types