Across TCGA cell cohorts, TMEM116 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,997 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM116-associated GO terms across cancer lineages are Blood coagulation, intrinsic pathway, Cold acclimation, and Angiogenesis. Each is linked with TMEM116 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM116-to-partner and partner-to-TMEM116 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM116→partner) and Y-score (partner→TMEM116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Blood coagulation, intrinsic pathway →	-0.397	-1.954	<.001	<.001	3	12
OESOPHAGUS	Cold acclimation →	+0.157	+0.960	<.001	.005	3	9
LUNG_NSCLC_LUSC	Angiogenesis →	-0.096	-1.670	.001	<.001	3	9
CNS	Negative regulation of macrophage chemotaxis →	-0.180	-0.583	.007	<.001	3	9
URINARY_TRACT	Vesicle coating →	+0.080	+0.959	.001	.002	3	9
OESOPHAGUS	Sperm motility →	-0.123	-1.081	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,997 associations by consensus.

Exploration

TMEM116 survival (RNA) · tumor vs normal (RNA) · all TMEM116 data types