Across TCGA cell cohorts, TMEM116 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM116-associated genes across cancer lineages are GML, LGI1, and GFRA4. Each is linked with TMEM116 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM116-to-partner and partner-to-TMEM116 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM116→partner) and Y-score (partner→TMEM116) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.057	+4.152	.007	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	1
BLOOD_Leukemia	KERA →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	LRIT1 →	+0.041	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.067	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

TMEM116 survival (RNA) · tumor vs normal (RNA) · all TMEM116 data types