TMEM115

Across TCGA pan-cancer cohorts, TMEM115 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TMEM115 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM115 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM115 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where TMEM115 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.807	0.480	.007	21	view →
LUAD	DFS	Median	All	1.000	0.898	.021	6	view →
CCRCC	DFS	Quartile	All	0.900	0.603	.035	2	view →
GBM	OS	Quartile	All	0.696	0.960	.020	2	view →
LSCC	OS	Median	All	0.777	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TMEM115–HNSC (DFS)

Open the HNSC breakdown →