TMEM115

Across TCGA patient cohorts, TMEM115 protein abundance is significantly associated with the RNA expression of many other genes, with 8,892 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TMEM115-associated genes across cancer lineages are DNAJC2, NELFCD, and JRK. Each is linked with TMEM115 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM115-to-partner and partner-to-TMEM115 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM115 versus DNAJC2 in OV, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM115→partner) and Y-score (partner→TMEM115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DNAJC2 →	-0.404	-0.369	.001	.001	3	4
LSCC	NELFCD →	-0.431	-0.161	.003	.006	3	4
BRCA	JRK →	-0.624	-0.322	<.001	.001	3	4
HNSC	ENTPD1 →	+0.404	+0.181	.001	.001	3	3
COAD	PLEKHA4 →	-0.751	-0.489	.002	.001	3	3
PDAC	ASCC1 →	-0.324	-0.428	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,892 associations by consensus.

TMEM115 vs DNAJC2 — OV

Explore this scatter interactively →