TMEM115

Across TCGA patient cohorts, TMEM115 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM115-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Myosin-IIa_pS1943. Each is linked with TMEM115 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM115-to-partner and partner-to-TMEM115 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM115-low versus TMEM115-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM115→partner) and Y-score (partner→TMEM115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.254	-2.321	.029	.034	3	1
UCEC	Ku80 →	+0.318	+1.887	.003	.031	3	1
UCEC	Myosin-IIa_pS1943 →	+0.189	+1.887	.049	.031	3	1
UCEC	Notch1 →	+0.167	+2.820	.010	.035	3	1
UCEC	p62 Lck ligand →	+0.503	+3.700	<.001	.001	3	1
UCEC	PCNA →	+0.299	+2.321	.002	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by TMEM115 expression — UCEC

Explore this box plot interactively →