TMEM115

Across TCGA cell cohorts, TMEM115 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM115-associated genes across cancer lineages are C20orf85, IL22, and OR4F15. Each is linked with TMEM115 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM115-to-partner and partner-to-TMEM115 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by TMEM115-low versus TMEM115-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM115→partner) and Y-score (partner→TMEM115) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LRRTM3 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR2A5 →	+0.021	+4.922	<.001	.009	3	1
LARGE_INTESTINE	EIF3L →	+0.518	+3.237	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

C20orf85 by TMEM115 expression — BLOOD_Leukemia

Explore this box plot interactively →