TMEM11

Across TCGA patient cohorts, TMEM11 mutation is significantly associated with the RNA expression of many other genes, with 776 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM11-associated genes across cancer lineages are LINC02151, RPL31P9, and H4C12. Each is linked with TMEM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM11-to-partner and partner-to-TMEM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02151 grouped by TMEM11-low versus TMEM11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM11→partner) and Y-score (partner→TMEM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02151 →	+0.099	+5.362	<.001	.005	3	1
BLCA	RPL31P9 →	+0.268	+7.640	<.001	.009	3	1
UCEC	H4C12 →	+0.635	+2.606	.003	.006	3	1
UCEC	LINC02348 →	+0.631	+2.134	<.001	.007	3	1
UCEC	TAF9 →	+0.596	+3.480	.001	.002	3	1
UCEC	UHRF1 →	+0.982	+3.332	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

LINC02151 by TMEM11 expression — SKCM

Explore this box plot interactively →