TMEM11

Across TCGA cell cohorts, TMEM11 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,381 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM11-associated GO terms across cancer lineages are Glycine biosynthetic process, DTMP biosynthetic process, and Telomere assembly. Each is linked with TMEM11 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMEM11-to-partner and partner-to-TMEM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycine biosynthetic process grouped by TMEM11-low versus TMEM11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM11→partner) and Y-score (partner→TMEM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Glycine biosynthetic process →	+0.216	+0.587	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DTMP biosynthetic process →	+0.124	+0.469	.005	.002	2	11
LUNG_SCLC	Telomere assembly →	+0.123	+0.699	<.001	<.001	3	10
LARGE_INTESTINE	5-phosphoribose 1-diphosphate metabolic process →	+0.152	+0.882	<.001	.004	3	10
LARGE_INTESTINE	5-phosphoribose 1-diphosphate biosynthetic process →	+0.152	+0.882	<.001	.004	3	10
UPPER_AERODIGESTIVE_TRACT	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.124	+0.469	.005	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,381 associations by consensus.

Glycine biosynthetic process by TMEM11 expression — BONE

Explore this box plot interactively →