TMEM109

Across TCGA patient cohorts, TMEM109 protein abundance is significantly associated with the RNA expression of many other genes, with 10,830 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM109-associated genes across cancer lineages are AURKAIP1, NDUFS1, and ACTR5. Each is linked with TMEM109 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM109-to-partner and partner-to-TMEM109 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM109 versus AURKAIP1 in UCEC, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM109→partner) and Y-score (partner→TMEM109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AURKAIP1 →	-1.440	-0.648	<.001	<.001	3	4
CCRCC	NDUFS1 →	-0.318	-0.300	.005	.002	3	4
LSCC	ACTR5 →	-0.549	-0.270	<.001	<.001	3	3
GBM	TLR8 →	+0.671	+0.205	<.001	.003	3	3
GBM	IL21R →	+0.860	+0.298	<.001	<.001	3	3
UCEC	DVL1 →	-0.914	-0.528	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,830 associations by consensus.

TMEM109 vs AURKAIP1 — UCEC

Explore this scatter interactively →