TMEM109

Across TCGA patient cohorts, TMEM109 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM109-associated genes across cancer lineages are eEF2, Notch1, and PCNA. Each is linked with TMEM109 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM109-to-partner and partner-to-TMEM109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TMEM109-low versus TMEM109-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM109→partner) and Y-score (partner→TMEM109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.397	+2.321	.004	.033	3	2
UCEC	Notch1 →	+0.137	+2.469	.013	.010	3	2
UCEC	PCNA →	+0.362	+3.087	<.001	<.001	3	2
UCEC	PTEN →	-0.480	-2.459	.002	.019	3	2
UCEC	ATM →	-0.699	-3.169	<.001	<.001	3	2
UCEC	eIF4E →	+0.225	+3.335	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by TMEM109 expression — UCEC

Explore this box plot interactively →