TMEM109

Across TCGA cell cohorts, TMEM109 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,820 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM109-associated GO terms across cancer lineages are DNA replication initiation, Regulation of chromosome separation, and Spindle elongation. Each is linked with TMEM109 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMEM109-to-partner and partner-to-TMEM109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by TMEM109-low versus TMEM109-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM109→partner) and Y-score (partner→TMEM109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DNA replication initiation →	+0.144	+0.925	<.001	<.001	2	12
CNS	Regulation of chromosome separation →	+0.066	+0.551	.001	<.001	3	11
BLOOD_Lymphoma	Spindle elongation →	+0.149	+0.863	.002	<.001	3	11
OESOPHAGUS	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.131	+1.108	<.001	<.001	3	10
LARGE_INTESTINE	Mitotic spindle elongation →	+0.181	+0.769	<.001	.002	3	10
LARGE_INTESTINE	Mitotic spindle midzone assembly →	+0.181	+0.769	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,820 associations by consensus.

DNA replication initiation by TMEM109 expression — OVARY

Explore this box plot interactively →