TMEM106C

Across TCGA pan-cancer cohorts, TMEM106C Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM106C data layer compared with 26 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM106C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM106C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, KIRP, and UCEC are the cancer types where TMEM106C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.140	0.783	<.001	18	view →
KIRP	OS	Median	All	0.272	0.885	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.624	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM106C–COAD (DFS)

Open the COAD breakdown →