Across TCGA patient cohorts, TMEM106A RNA expression is significantly associated with the protein abundance of many other proteins, with 19,511 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM106A-associated proteins across cancer lineages are DAB2, SIPA1, and SNX2. Each is linked with TMEM106A in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM106A-to-partner and partner-to-TMEM106A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106A→partner) and Y-score (partner→TMEM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DAB2 →	+0.840	+0.666	<.001	<.001	3	9
COAD	SIPA1 →	+0.307	+0.516	.001	.009	2	9
GBM	SNX2 →	+0.224	+0.593	<.001	<.001	3	8
OV	WIPF1 →	+0.558	+0.736	<.001	<.001	3	7
GBM	ALOX5 →	+0.830	+0.683	<.001	<.001	3	7
GBM	HCK →	+0.891	+0.771	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,511 associations by consensus.

Exploration

TMEM106A survival (RNA) · tumor vs normal (RNA) · all TMEM106A data types