Across TCGA patient cohorts, TMEM106A protein abundance is significantly associated with the RNA expression of many other genes, with 4,245 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM106A-associated genes across cancer lineages are PDCD1, MNDA, and EIF3L. Each is linked with TMEM106A in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM106A-to-partner and partner-to-TMEM106A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106A→partner) and Y-score (partner→TMEM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PDCD1 →	+0.899	+0.502	<.001	<.001	3	3
LSCC	MNDA →	+1.038	+0.497	<.001	<.001	3	3
LSCC	EIF3L →	-0.672	-0.607	<.001	.004	3	2
LSCC	CBX1 →	-0.837	-0.514	<.001	<.001	3	2
LSCC	METAP2 →	-0.510	-0.562	.001	<.001	3	2
LSCC	CEP68 →	-0.364	-0.368	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,245 associations by consensus.

Exploration

TMEM106A survival (RNA) · tumor vs normal (RNA) · all TMEM106A data types