Across TCGA patient cohorts, TMEM106A mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM106A-associated genes across cancer lineages are Rb_pS807_S811, Annexin-1, and VHL. Each is linked with TMEM106A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM106A-to-partner and partner-to-TMEM106A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106A→partner) and Y-score (partner→TMEM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rb_pS807_S811 →	-0.406	-2.321	.046	.035	3	1
UCEC	Annexin-1 →	+0.586	+2.827	.026	.035	3	1
UCEC	VHL →	-0.861	-2.321	.011	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.914	+3.019	.002	.019	3	1
UCEC	c-Jun_pS73 →	-0.203	-3.459	.011	.005	3	1
UCEC	c-Met_pY1235 →	+0.074	+3.459	.047	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TMEM106A survival (RNA) · tumor vs normal (RNA) · all TMEM106A data types