Across TCGA cell cohorts, TMEM106A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,450 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TMEM106A-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Regulation of protein localization to mitochondrion, and Intracellular receptor signaling pathway. Each is linked with TMEM106A in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM106A-to-partner and partner-to-TMEM106A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106A→partner) and Y-score (partner→TMEM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Cytoplasmic pattern recognition receptor signaling pathway →	+0.080	+0.846	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Regulation of protein localization to mitochondrion →	+0.109	+1.195	.009	.006	3	10
SOFT_TISSUE	Intracellular receptor signaling pathway →	+0.062	+1.218	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Maintenance of protein location →	+0.132	+1.413	.001	<.001	3	10
LUNG_NSCLC_LUSC	Maintenance of protein localization in organelle →	+0.137	+1.404	<.001	<.001	3	10
SOFT_TISSUE	Positive regulation of protein localization to mitochondrion →	+0.082	+1.019	.003	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,450 associations by consensus.

Exploration

TMEM106A survival (RNA) · tumor vs normal (RNA) · all TMEM106A data types