Across TCGA cell cohorts, TMEM106A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM106A-associated genes across cancer lineages are MYF5, MYOD1, and ADGRA1. Each is linked with TMEM106A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM106A-to-partner and partner-to-TMEM106A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106A→partner) and Y-score (partner→TMEM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MYOD1 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
SKIN	HTR1A →	+0.006	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TMEM106A survival (RNA) · tumor vs normal (RNA) · all TMEM106A data types