Across TCGA pan-cancer cohorts, TMEM105 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM105 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TMEM105 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM105 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LGG, LIHC, and UCEC are the cancer types where TMEM105 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.195	0.845	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.443	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM105 tumor-vs-normal RNA expression · all TMEM105 data types