Across TCGA patient cohorts, TMEM105 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,131 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TMEM105-associated proteins across cancer lineages are CLASP2, MVP, and PPP1R14C. Each is linked with TMEM105 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM105-to-partner and partner-to-TMEM105 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM105→partner) and Y-score (partner→TMEM105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLASP2 →	-0.226	-0.742	.002	<.001	3	4
LUAD	MVP →	+0.469	+0.723	<.001	<.001	3	3
BRCA	PPP1R14C →	+0.867	+0.503	.002	<.001	3	3
HNSC	DARS1 →	+0.233	+0.459	<.001	<.001	3	3
HNSC	DCTPP1 →	+0.328	+0.412	.002	<.001	3	3
LUAD	DNAJC1 →	-0.397	-0.755	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,131 associations by consensus.

Exploration

TMEM105 survival (RNA) · tumor vs normal (RNA) · all TMEM105 data types