Across TCGA patient cohorts, TMEM105 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM105-associated genes across cancer lineages are IGHV1OR15-6, LINC01050, and GM2AP1. Each is linked with TMEM105 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM105-to-partner and partner-to-TMEM105 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM105→partner) and Y-score (partner→TMEM105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV1OR15-6 →	+0.276	+4.318	.008	<.001	3	1
UCEC	LINC01050 →	+0.273	+3.801	.007	.005	3	1
SKCM	GM2AP1 →	+0.084	+3.402	<.001	.007	3	1
SKCM	ADGRL3-AS1 →	+0.120	+3.240	<.001	.005	3	1
BLCA	MIR3160-1 →	+0.392	+6.289	<.001	.001	3	1
COAD	OR4C46 →	+0.179	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

TMEM105 survival (RNA) · tumor vs normal (RNA) · all TMEM105 data types