TMEM104

Across TCGA pan-cancer cohorts, TMEM104 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM104 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TMEM104 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM104 expression acts as an unfavorable survival marker.

BRCA, LUAD, and COAD are the cancer types where TMEM104 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.233	0.833	<.001	12	view →
LUAD	DFS	Median	III,IV	0.036	0.673	<.001	9	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TMEM104–BRCA (OS)

Open the BRCA breakdown →