TMEM104

Across TCGA pan-cancer cohorts, TMEM104 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM104 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM104 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM104 expression acts as an unfavorable survival marker.

HNSC and LUAD are the cancer types where TMEM104 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.429	0.903	<.001	40	view →
LUAD	DFS	Quartile	All	0.421	0.888	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

TMEM104–HNSC (DFS)

Open the HNSC breakdown →