TMEM104

Across TCGA patient cohorts, TMEM104 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM104-associated genes across cancer lineages are eIF4E, MSH6, and mTOR_pS2448. Each is linked with TMEM104 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM104-to-partner and partner-to-TMEM104 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TMEM104-low versus TMEM104-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM104→partner) and Y-score (partner→TMEM104) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.234	+2.807	.011	.003	3	2
UCEC	MSH6 →	-0.493	-2.999	<.001	.035	3	2
UCEC	mTOR_pS2448 →	-0.158	-3.156	.015	.018	3	2
UCEC	Annexin-1 →	+0.534	+3.189	.020	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.781	+2.604	.002	.005	3	2
COAD	Fibronectin →	+0.769	+2.815	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by TMEM104 expression — UCEC

Explore this box plot interactively →